Ruta Colombina is in the Canary Islands and not in Huelva
a "Ruta Colombina" in Huelva which forms the basis for the current T List site of "Monastery of Santa María de La Rábida and the Columbus Memorial Places in Huelva". I have recently returned from it!
See - - http://www.huelvatour.com/ruta-colombina.htm
In addition to the Gran Canaria Colombus "house", La Gomera (Canaries) also has a house considered to have been used by him and some articles refer to it as being on the "Route of Colombus" but meaning in this case HIS actual route rather than a tourist route - see the wording of this link (and the contents of the article)- http://www.herreracasado.com/1988/07/01/por-la-ruta-colombina-del-descubrimiento-la-g omera-isla-colombina/
But I can't find anything describing a genuine "Ruta" on the Canaries and the sites in/around Huelva still seem "more likely" to me as the current "manifestation" of this T List site
Similarly there is a Hospital Real de Sta Cruz in Toledo. See our history of the Toldeo site here - https://www.worldheritagesite.org/list/Toledo
(Els/Assif do you understand/remember the origin of this comment in our history of the Toledo site - I can't trace it?? Perhaps it is incorrect? It isn't exactly "logical" or supported by early UNESCO documentation etc)
But I agree that the Granada example seems more liikely - https://es.wikipedia.org/wiki/Hospital_Real_de_Granada